Faculty of Physics

Ֆիզիկայի ֆակուլտետ

Faculty of Physics

The process of training specialists in the field of physics and mathematics began in 1922 in YSU.:

Samvel G. Haroutiunian

Professor | Faculty of Physics

Education
1977: Graduated from Faculty of Physics, Yerevan State University

Academic degree
Candidate of phys. - math. sci. (03.00.02-Biophysics) - “The influence β-alanine and γ –ABA on structure and stability of DNA”, 1984, Institute of Physics of Georgian Academy of Science, Tbilisi.
Doctor of phys. - math. sci.(01.00.07 - Solide State Physics and 03.00.02-Biophysics) - “The influence of ligands on DNA as an one dimensional”, 1993, Institute of Applied Problem of Physics of Armenian Academy of Science, Yerevan.

Professional experience
2007: Chairman of Committee of Science of RA
2006 - 2007: Vice Rector of YSU
2000 - 2006: Dean of Faculty of Physics of YSU
1994 - 2000: Head of Department of Molecular Physics, Faculty of Physics, YSU
1992 - 1994: Head of laboratory of Macromolecular Physics on Department of Molecular Physics, Faculty of Physics, YSU
1991 - 1992: head Investigator of laboratory of Macromolecular Physics on Department of Molecular Physics, Faculty of Physics, YSU
1988 - 1991: Visiting professor at the University of Florence, Italy
1985 - 1988: Senior Scientific Researcher of laboratory of Macromolecular Physics on Department of Molecular Physics, Faculty of Physics, YSU
1983 - 1985: Junior Scientific Researcher of laboratory of Macromolecular Physics on Department of Molecular Physics, Faculty of Physics, YSU
1981 - 1983: Senior Lab. Assistant of Department of Molecular Physics, Faculty of Physics, YSU
1977 - 1980: PhD student of Department of Molecular Physics, Faculty of Physics, YSU

Academic courses
"Actual problems of physics of macromolecules " and "DNA-ligand interaction" for 1-st year master students of YSU,
"Physics of Biopolymers" for postgraduate students, YSU

Scale of professional interests
The investigation of selectivity of interaction of low molecular ligand with DNA. Determination of molecular mechanisms of interaction of DNA with antitumor (cis-platin) and potential antitumor (Pt- and Ru- complexes, porphyrins and metalloporphyrins) preparations

Participation in grant projects
1994: RYX000 from International Science Foundation
1998 - 1999: CRDF #AB1-963/ NFSAT #ACB-014-98
1999 - 2000: ISTC #A-301.1
2000 - 2001: CRDF #AB2-2006
2002 - 2004: NFSAT #MB 078/CRDF #12027
2002 - 2006: ISTC A-773
2002 - 2007: ISTC #A-301.2
2003 - 2004: NATO LST.CLG.979777
2011 - 2013: Armenian-Belarus grant, #11РБ-017
2013 - 2015: Grant of SCS RA #13-1F094

Professional membership
Vice Chairmen of Special Council 021 High Attestation Commission at Institute of Applied Problem of Physics of Armenian Academy of Science
Member of the 051 - “Biophysics” Special Council of High Attestation Commission of Armenia

Awards received
2009 Gold Medal of YSU, RA
2009 Medal of S.P.Korolev, RF
2009 Honor of Prokhorov, RF
2014 Medal of V.Sargsyan, RA

Languages
Armenian, Russian, English, Italian

sharout@ysu.am

L. R. Aloyan , Y. B. Dalyan , S.G Haroutiunian

The influence of CuTOEPyP4 porphyrin on DNA damage induced by high energy electron beam radiation.

2019 | Article

Albany 2019: 20th Conversation, 85-86 էջ

L.R. Aloyan , Y.B. Dalyan , S.G. Haroutiunian

The influence of FeTOEPyP4 porphyrins on DNA damage induced by high energy electron beam radiation.

2019 | Article

International Conference on Nuclear and Radiation Physics and Materials: NRPM 2019, 68 էջ

Gohar Tsakanova, Elina Arakelova, Violetta Ayvazyan, Anna Ayvazyan, Stepan Tatikyan, Rouben Aroutiounian , Yeva Dalyan , Samvel Haroutiunian , Vasili Tsakanov, Arsen Arakelyan

Two-photon microscopy imaging of oxidative stress in human living erythrocytes

2017 | Article

Biomedical optics express. 2017, Vol. 8, No. 12, 5834-5846 pp.

Н. Г. Каpапетян , Г. В. Ананян , Е. Б. Далян , C. Г. Аpутюнян

Плавление ДНК опуxоленоcящиx кpыc, леченыx мезо-тетpа(4-n-гидpокcиэтилпиpидил)поpфиpином и его AG-, ZN-, CO-пpоизводными

2017 | Article

Биофизика. 2017, 62, 3, стр. 458–463

Galina Hovhannisyan , Bagrat Grigoryan, Ruzanna Grigoryan, Natalia Sarkisyan, Gohar Tsakanova, Samvel Haroutiunian , Rouben Aroutiounian

Dose-rate effect of ultrashort electron beam radiation on DNA damage and repair in vitro

2017 | Article

Journal of Radiation Research. 2017, 3, 1-4

Gohar Tsakanova, Elina Arakelova, Violetta Ayvazyan, Anna Ayvazyan, Stepan Tatikyan, Rouben Aroutiounian, Yeva Dalyan , Samvel Haroutiunian , Vasili Tsakanov, Arsen Arakelyan

Two-photon microscopy imaging of oxidative stress in human living erythrocytes․

2017 | Article

BIOMEDICAL OPTICS EXPRESS, 2017, Vol. 8, No. 12, 5834-5846 pp.

N. H. Karapetyan , A. L. Torosyan, M. Malakyan, S. A. Bajinyan, S. G. Haroutiunian

Investigation of irradiated rats DNA in the presence of Cu(II) chelates of amino acids Schiff bases

2016 | Article

Journal of biomolecular structure & dynamics. 2016, 34(1), 177-183 pp.

V. M. Tsakanov , R. M. Aroutiounian , G. A. Amatuni, L. R. Aloyan , L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan , H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian , V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh.Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, G. S. Zanyan

AREAL low energy electron beam applications in life and materials sciences

2016 | Article

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2016, Volume 829, 248-253 pp.

G. V. Ananyan , N. H. Karapetyan , S. G. Haroutiunian , Y. B. Dalyan

The features of complex formation of poly(dI-dC)2with porphyrins

2015 | Thesis

Albany 2015:19th Conversation Journal of Biomolecular Structure and Dynamics, V.33, S.1., 2015, p. 85. DOI:10.1080/07391102.2015.1032765

G. V. Ananyan, N. H. Karapetyan , S. G. Haroutiunian , Y. B. Dalyan

The features of complex formation of poly(dI-dC)2 with porphyrins

2015 | Thesis

J. Biomolecular Structure and Dynamics, Vol. 33, S1, No.132, p.85, (2015)

V. G. Barkhudaryan , G. V. Ananyan , Y. B. Dalyan , S. G. Haroutiunian

Development of viscometric methods for studying the interaction of various porphyrins with DNA

2014 | Article

Part I: meso-tetra-(4N-hydroxyethylpyridyl) porphyrin and its Ni-, Cu-, Co- and Zn- containing derivatives. Journal of Porphyrins and Phthalocyanines 2014 18:07, 594-599. DOI: 10.1142/S1088424614500357

V. G. Barkhudaryan , G. V. Ananyan , Y. B. Dalyan , S. G. Haroutiunian

Development of viscometric methods for studying the interaction of various porphyrins with DNA. Part I: meso-tetra-(4N-hydroxyethylpyridyl) porphyrin

2014 | Article

J. Porphyrins and Phthalocyanines, N 18, p. 594–599, (2014)

Самвел Геворгян , Анатолий Арабский, Самвел Арутюнян , Феликс Дедученко, Сергей Харьков

Обеспечение техногенной безопасности: есть решение!

2013 | Article

Комплексная Безопасность Отечества (Информационно-аналитический журнал Парламентского Центра Российской Федерации ),2013, № 2(3), стр. 39-41

D.Y. Lando, I.E.Grigoryan, E.N. Galyuk, A.S. Fridman, Y.B. Dalyan , S.G. Haroutiunian

Kinetics of DNA thermal stability in the presence of cisplatin

2013 | Article

Biological Journal of Armenia, 3(65), p. 14-22, (2013)

D.Y. Lando, I.E. Grigoryan, A.S. Fridman, E.N. Galyuk, Y.B. Dalyan , S.G. Haroutiunian

Evaluation of errors in determination of DNA melting curve registered with differential scanning calorimetry

2013 | Article

Biological Journal of Armenia, 2(65), p.6-12, (2013)

Karapetyan N. H. , Malakyan M. H., Bajinyan S. A., Torosyan A. L. , Grigoryan I. E., Haroutiunian S. G.

Influence of Amino Acids Shiff Bases on Irradiated DNA Stability In Vivo

2013 | Article

Cell biochemistry and biophysics. 2013, 67,1137-1145 pp.

D.Y. Lando, C.L. Chang, I.E. Grigoryan, S.G. Haroutiunian , Y.B. Dalyan , C.-K. Hu

A Computer program for differential scanning micro- and nano- calorimeters

2012 | Article

The International Scientific Conference “Molecular, Membrane and Cellular bases of functioning biosystems and the X Congress of Belarusian Public Association of photobiologists and biophysicists”, June 19-21, Minsk, Belarus, 2012, № 2, p. 288-290

Arakelyan V. , Harutyunyan S. , Andriasyan V., Arakelyan H.

Isotherm of Ligand Adsorption on DNA at Multiplicative Noise

2012 | Article

J. Biomol. Struct. Dyn., 2012, v.30, N2, p. 217-222

I. E. Grigoryan , Ye. B. Dalyan , S. G. Haroutiunian

Comparative analysis of the effects of platinum compounds on thermostability of DNA (ԴՆԹ-ի ջերմակայունության վրա պլատինային միացությունների ազդեցության համեմատական ուսումնասիրություններ )

2011 | Article

ԵՊՀ գիտական տեղեկագիր, Ֆիզիկա և մաթեմատիկա, 2011, #3, էջ 52–57

I.E. Grigoryan, S.G. Haroutiunian

Comparison of the effects of two platinum coordination complexes on the thermostability of DNA

2010 | Thesis

“Solvation and Ionic Effects in Biomolecules: Theory to Experiment”, May 17-21, 2010, Tsakhkadzor, Armenia, Abstract Book, p. 65

Y.Dalyan , L.Abgaryan, G.Sarkisyan, S.Haroutiunian

Comparative analysis of the effects of Cu and Ni ions on the thermostability of DNA

2008 | Article

Electronic Journal of NAS of RA, 2(11), 2008, p.7-10

J. Monaselidze, G. Majagaladze, Sh. Barbakadze, D. Khachidze, M. Gorgoshidze, Y. Kalandzdze, S. G. Haroutiunian , Y. B. Dalyan , V. I. Vardanyan

Microcalorimetric Investigation of DNA, poly(dA)poly(dT) and poly[d(A C)]poly[d(G T)] melting in the presence of Water Soluble (Meso tetra (4 N oxyethylpyridyl) Porphyrin) and its Zn Complex

2007 | Article

Journal of Biomol. Structure & Dynamics, 2007, v. 25, No. 4, p. 419-424

S.Haroutiunian , Y.Dalyan , A.Ghazaryan, T.Chalikian

Thermodinamic profile of interaction of porphyrins with nucleic acids

2007 | Article

Brilliant Light in Life and Material Science, V. Tsakanov & H.Wiedemann (eds), 2007, Springer, p. 213-218

, Y.Dalyan , S.Haroutiunian , A.Tikhomirova, N.Taulier, J.W. Wells, T.V.Chalikian

Thermodynamics of Interactions of Water-Soluble Porphyrins with RNA Duplexes

2006 | Article

J. Amer. Chem. Soc., 2006, 128, No. 6, p.1914-1921

A. A. Ghazaryan, Ye. B. Dalyan , S. G. Haroutiunian , T. V. Chalikyan

Спектральное исследование взаимодействий TAlPyP(4) и AgTAlPyP(4) с poly(rG)poly(rC), poly(rI)poly(rC) и poly(rA)poly(rU) (TAlPyP(4)-ի և AgTAlPyP(4)-ի հետ poly(rG)poly(rC)-ի, poly(rI)poly(rC)-ի և poly(rA)poly(rU)-ի փոխազդեցությունների սպեկտրալ ուսումնասիրությունը)

2005 | Article

ԵՊՀ Գիտական տեղեկագիր, Բնական գիտություններ, 2005, #3, էջ 73-79 (ռուսերեն)

Ananyan G. V. , Vardanyan V.I., Dalyan Y. B , Haroutiunian S. G

Interaction of Co-containing meso-tetra-(N-pyridil) porphyrins with DNA

2005 | Thesis

Int. Symposium on Hydration and Thermodynamics of Molecular Recognition, Tsakhkadzor, Armenia, Mar. 1-5, Book of Abstracts, 2005, p.54

S. G. Haroutiunian , V. I. Vardanyan, Ye. B. Dalyan

Особенности комплексообразования макромолекул ДНК с низкомолекулярными лигандами (ԴՆԹ-ի մակրոմոլեկուլի կոմպլեքսառաջացման առանձնահատկությունները ցածրմոլեկուլային լիգանդների հետ)

2004 | Article

ԵՊՀ Գիտական տեղեկագիր, Բնական գիտություններ, 2004, #3, էջ 3-34 (ռուսերեն)

S.Haroutiunian , V.Vardanyan, Y.Dalyan

The peculiarity of complexation of DNA macromolecule with low molecular ligands

2004 | Article

Scientific Reports of YSU, 2004, v.3, No.205 p.3-34 (in Russian)

Arakelyan V. B. , Haroutiunian S. G. , Abgaryan G. A., Arakelyan H. V., Haroutunyan T. S.

Ligand Binding With Continuous Modification of Binding Sites

2004 | Article

J. Biomol. Struct. Dyn., 2004, v.22, N2, p. 245-252

Y. Dalyan , N. Karapetyan , S. Haroutiunian , G. Ananyan , L. Aloyan , V. Vardanyan, T. Chalikian

Binding of New Meso-Tetra-(3N-Pyridil) Porphyrins to DNA

2003 | Thesis

HUPO 2nd Annual and IUBMB XIX World Congress, October 8-11, Monreal.Molecular and Cellular Proteomics, 2003. v.2, # 9, p.972

Dalyan Y.B. , Haroutiunian T.S. , Haroutiunian S.G. , Vardevanyan P.O.

Melting of complexes of DNA-cis-DDP in acidic environment

2003 | Article

Experimental and Molecular Medicine, 2003, v. 35, N 6, pp. 534-537

Haroutunian T.S. , Sarkisyan Sh.S., Antonyan A.P., Haroutunian S.G. , Dalyan Y.B , Vardevanyan P.O

Melting of complexes of DNA-cis-DDP in acidic Media

2003 | Thesis

J. Biomol. Struct. & Dyn. 13th Conversation, Albany, USA, 2003, v. 20, N 6, p. 886

Arakelyan V.B. , Haroutunian S.G. , Arakelyan H.V., Haroutunian T.S

Adsorption of ligands on macromolecules in the fluctuating medium

2002 | Article

J. Biomol. Struct. & Dyn., 2002, v. 20, N 1, p. 1-5

ArakelyanV. B. , Haroutiunian S. G. , Arakelyan H. V., Haroutunyan T. S.

Adsorption of ligands on macromolecules in the fluctuating medium

2002 | Article

J. Biomol. Struct. Dyn., 2002, v.20, N1, p. 125-130

Y. B. Dalyan , S. G. Haroutiunian , G. V. Ananyan , V. I. Vardanyan, D. Y. Lando, V. N. Madakyan, R. K. Kazaryan, L. Messori, P.L. Orioli, A. S. Benight

Interactions of Meso-tetra-(4-N-oxyethylpyridyl) Porphyrin, Its 3-N Analog and Their Metallocomplexes with Duplex DNA

2001 | Article

Journal of Biomol. Structure & Dynamics, 2001, v. 18, 677-687

Далян Е.Б. , Арутюнян С.Г. , Ананян Г.В.

Комплексообразование металлопорфиринов с ДНК. Эффект центрального металла

2001 | Thesis

II Межд. Симпозиум “Проблемы биохимии, радиационной и космической биологии” посвященной памяти акад. Н.М.Сисакяна. Москва, Дубна, 29-31 мая 2001, Тезисы докладов, с. 74

Dalyan Y. B. , Haroutiunian S. G. , Ananyan G. V.

The structural peculiarities of some DNA – porphyrin complexes

2000 | Thesis

Int. Conf.DNA Conformation, Modification and Recognition in Biomedicine, 2000, Jule 2-5 Brno, Chech. Republic, Book of Abstracts, p.76

L.Messori, A.Casini, D.Vullo, Y.B.Dalyan , S.G.Haroutiunian , P. Orioli

Effect of two representative antitumor ruthenium(III) complexes on thermal denaturation profiles of DNA

2000 | Article

Inorganica Chimica Acta, 2000, 303, p. 283-286

Dalyan Y. B. , Haroutiunian S. G. , Ananyan G. V. , Sahakyan L.A, Madakyan V. N, Kazaryan R. K.

The structural properties of DNA–Metalloporphyrin complexes

1999 | Thesis

5-th Int. Symp. On Applied Bioinorganic Chemistry (5ISASC), 1999, 13-17 April, Corfu, Greece, Book of Abstracts, p.281

S.G. Haroutiunian , E.B. Dalian , N.H.Karapetian

The Specific Influence of External Medium on Order-Desorder Transition of DNA

1998 | Article

Int. Symp.Yerevan, 1998

Haroutiunian S.G. , Dalyan Y.B. , Morozov V.F. , Mamasachlissov Eu.Sh. , Shahinian M.S., Akhrem A.A., Lando D.Yu., Messori L., Orioli P.

Influence of cis- and trans-diamminedichloroplatinum(II) binding on the helix-coil transition of DNAs with different GC-content

1998 | Article

Inorganica Chimica Acta, 1998, 275-276, 510-514

Haroutiunian S.G , Mamasakhlissov Eu.Sh. , Dalyan Y.B. , Morozov V.F. , Khachikyan R.E., Vardevanyan P.O., Karapetyan A.T, P.Oriօli, B.Bruni

The modification of the spatial structure of DNA in its complexes with cis-DDP

1997 | Article

Biophysics 1997, 42, 372-377. (in Russian)

Haroutiunian S.G. , Vardevanian P.O. , Dalian E.B. , Antonian A.P., Karapetian A.T., Terzikian G.A.

DNA modification in DNA-cis-platinum complexes

1995 | Thesis

Journal of Biomol. Structure & Dynamics, 1995, 12, 86

S.G. Haroutiunian , P.O. Vardevanian , E.B. Dalian , A.T. Karapetian , G.A. Terzikian , N.H.Karapetian

The possible Structure DNA modifications in the presense of cisplatinum

1995 | Article

Int. Conf. on Molecular Structural Boilogy, Viena, 1995

, Samvel G. Haroutiunian , Yeva B. Dalyan , , ,

Theoretical and experimental study of DNA helix-coil transition in acidic and alkaline medium

1994 | Article

J. of Biomol. Structure & Dynamics, 1994, N 12, 355-362

Haroutiunian S.G. , Dalian E.B. , Khachikian R.E., Aslanian V.M.

Ionization specific influence of nitrogen bases on thermostability of AT- and GC-pairs of DNA

1990 | Article

Biophysics 1990, v.35, No.4, p.588-593. (in Russian)

Haroutiunian S.G. , Aslanian V.M., Dalyan Y.B. , Lando D.Yu., Akhrem A.A.

A new method for determining the relative effect of ligands on AT- and GC-base pairs in DNA: application to metal ions, protons and two amino acids

1990 | Article

Nucleic Acids Research, 1990, N 8, 6413-6418

Akhrem A.A. , Lando D.Yu, Haroutiunian S.G. , Dalian E.B. , Shpakovski A.G.

The helix-coil transitions in alkaline medium

1989 | Article

Molecular Biology, 1989, v.23, No.2, p.518-524 (in Russian)

Aslanian V.M., Haroutiunian S.G. , Dalian E.B. , Lando D.Yu., Shpakovski A.G.

The specific interaction of ligands on AT- and GC- base pairs of DNA

1988 | Thesis

Biophysics,1988, 33, 3, 430 (in Russian)

V. M. Aslanian, S. G. Harutyunian , Ye. B. Dalyan , H. S. Farshyan

Термическое плавление ДНК при щелочных pH (ԴՆԹ֊ի ջերմային հալումը հիմնային PH֊երի դեպքում)