Using histological, cytological, immunohistochemical methods, histomorphological changes in the mucous membrane of the upper respiratory tract of patients with COVID-19-associated mycoses will be examined in order to detect immune inflammation.
The data obtained will make it possible to identify the cytological patterns of the development of inflammatory processes, to find out the presence of immunopathological processes in conditions of exposure to mycofactors in the mucous membrane of patients with COVID-19-associated mycoses of the upper respiratory tract.
The results of the study will serve as the basis for the development of preventive and therapeutic measures in the fight against COVID-19.
Mycoses are diseases the exciter of which are pathogenic fungi. Currently 100 species of pathogenic fungi and 400 species of conditionally pathogenic fungi are known. These fungi are common in soil, mold spores and particles are always present in the air in cities, flats/houses, open areas. It is shown that the particles detached from the mycelium often contaminated surfaces and some of these fragments may remain viable and grow. The concentration of fragments of fungi in indoor air reaches the level 29 to 146 particles in mm.
In case of proper conditions the spores and particle of pathogenic fungi are penetrated into human’s tissue and cause mycotic processes. Molds produce toxic substances like mycotoxinswhich cause a number of pathogenic phenomena development in organism.
Currently in many countries are observed cases of mycosеs morbidity growth. This is due to a number of circumstances. First of all, it is the increase in diseases that are accompanied by immune deficiency. Mycosеs morbidity growth is also due to the uncontrolled use of antibiotics which stifle the growth of bacteria and cause dysbacteriosis. As a result a fungal infection is developed. Upper respiratory mycoses are observed quite often as the mucosa of these organs as well as the skin are the first bulwark against fungal infections and are the first place of deployment