Evaluation of molecular biological effects of subpicosecond pulses of accelerated electron beams irradiation in human normal and tumor cells

The main task of the project is the analysis of molecular mechanisms of radiobiological effects after irradiation of human normal and tumor cells with subpicosecond pulses of accelerated electron beams in different radiation regimenson AREAL (Advanced Research Electron Accelerator Laboratory, Armenia) laser driven radio-frequency gun based linear accelerator. The large scale systematic studies with analysis of key molecular and cellular parameters (induction of DNA damage and repair; cell cycle and proliferation arrest; cell death) will be performed. The results obtained will help to select the strategy of further research on application of ultrashort (subpicosecond) pulse irradiation for the development of new technologies of radiation therapy of malignant tumors.