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General information
One of the urgent tasks of radiobiology is research aimed at the possible enhancement of the effect of ionizing radiation on biological objects. This is especially true in radiation therapy, which aims to destroy tumor cells. In this case, the important task is to study the mechanisms of the influence of radiation on the DNA, since the primary cause of the "death" of cells is considered to their structure breaks. However, DNA damage can occur both in tumor and in closely spaced healthy cells, which can lead to many human diseases (side effects). The combination of radiation therapy with other cancer treatments (chemotherapy, phototherapy) has significantly changed the treatment of tumors. Some compounds used in chemotherapy, such as cisplatin, make radiation therapy more effective. In this project, we plan to identify the structural changes that occur in the DNA molecule when irradiated with an electron beam, when the solution contains the cisplatin used in chemotherapy and potentially phototherapeutic compounds - metallophyrins. The studies carried out make it possible to determine the optimal concentrations of the studied compounds depending on the radiation doses, as well as to determine the possible increase in the effect of radiation on DNA molecules.
