Histopathological characterization of neurodegenerative lesions in multiple sclerosis and prospects for therapy in animal models

This research project endeavors to delve into the histopathological intricacies of neurodegenerative lesions in multiple sclerosis (MS) through the use of animal models. MS, a chronic autoimmune disorder affecting the nervous system, triggers a cascade of inflammation, demyelination, and neurodegeneration. By scrutinizing the histopathological features of neurodegenerative lesions in animal models, we aim to unravel the underlying mechanisms fueling neurodegeneration in MS. The project entails meticulous examination of tissue samples harvested from animals exhibiting MS-like pathology. Through this analysis, we seek to pinpoint specific cellular and molecular transformations linked to neurodegenerative lesions. This encompasses assessing the distribution of inflammatory cells, delineating demyelination patterns, quantifying axonal damage, and gauging neuronal loss within the lesions. Furthermore, our endeavor extends to evaluating potential therapeutic interventions aimed at forestalling or ameliorating neurodegeneration in MS. In essence, this project strives to augment our comprehension of the pathophysiological landscape of neurodegeneration in MS, while concurrently pioneering novel therapeutic avenues to impede or decelerate the progression of this debilitating disease.