General information
Mushrooms are unique organisms rich in proteins and carbohydrates, which allows them to be used not only as food, but also in cosmetics and medicine. Previously, we showed an increase in the activity of enzyme systems and the anti-inflammatory effect of the mycelial extract of the fungus under the influence of mm waves, which is very promising for use in medicine. Within the framework of this project, the task is to obtain an environmentally friendly drug obtained from natural raw materials that does not have side effects. The mushroom extract has anticancer activity and can also used for reducing the side effects after chemotherapy. We propose irradiating the mycelium culture with mm waves to obtain an extract with increased anticarcinogenic activity. The extracts obtained by this way will be investiagted of its influence on human cancer cell lines HepG-2, RD, HEK 293, HEp-2 and HeLa. The dynamics of the extracts effect on cells will be tested on 3D spheroid models, and the slowdown in sphere growth will demonstrate the effectiveness of the extracts. The most effective extract will be further studied in vivo in rats, paving the way for the potential drug to be used to combat certain types of cancer.
Foreign Partner
Levon Abrahamyan, PhD in Biological Sciences, University of Montreal (Canada)
