General information
The research investigates bioactive compounds from medicinal plants in Armenia with high antioxidant activity, focusing on their effects on inflammatory processes and antioxidant system enzymes in microglial cell cultures. Given the role of oxidative stress and inflammation in neurodegenerative and cardiovascular diseases, these phytochemicals may offer protective effects. The study examines their impact on BV-2 wild type and ACOX1-deficient microglial cells, models for oxidative stress and neuroinflammation. Key methodologies include assessing antioxidant potential, cytotoxicity, and gene expression related to antioxidant enzymes and inflammation. The findings aim to advance understanding of how plant-derived antioxidants modulate oxidative stress and inflammation, potentially leading to the development of new treatments for neurodegenerative diseases. Results will be published and presented at scientific conferences, emphasizing the relevance and novelty of the study.
