General information
Amino acids offer a wide range of structural diversity due to the presence of different side chains and functional groups. On the other hand, thioflavin derivatives are widely known for their applications in various fields, including biology, medicine, and materials science, owing to their unique fluorescence properties and affinity for amyloid fibrils. By incorporating amino acid moieties into thioflavin derivatives, the resulting molecules can mimic the structural and functional properties of natural biomolecules, enhancing their compatibility and interaction with biological systems. The goal of the proposed project is to design, synthesize, and characterize a library of synthetic amino acids with thioflavin-like side chains. These novel derivatives will be evaluated for their potential anticancer activity, DNA and amyloid fibrils binding ability, and applications in bioimaging, disease diagnostics, and materials science.
