Targeted synthesis and study of the bioactivity of amino acids, peptidomimetics based on new benzo[h]quinazoline derivatives

Compounds containing a benzo[h]quinazoline fragment have not yet been found in nature; they are all synthetic and have a wide spectrum of biological activity. The review of the data shows that the biological activity largely depends on the structure of the derivatives, the nature of the substituents and the incorporation of functional groups into the basic structure of quinazolines. In recent years, among the derivatives of this heterocyclic system, compounds have been discovered that have anticonvulsant, psychotropic, antiviral, antitumor, antibacterial, anti-inflammatory, antitubercular and other beneficial properties. The synthesis of such compounds, as well as their introduction into the composition of amino acids, will allow synthesizing new bioactive molecules – peptidomimetics with the aforementioned properties, the production of which will be an interesting direction in pharmaceutical chemistry, which is planned to be implemented within this project. The selection of such ingredients will promote the benefits of biodegradability and biocompatibility, reduced side effects and longer half-life compared to protein analogs, and then the biological potential, especially antibacterial, antifungal and antitumor will be evaluated.