General information
The separation of chiral substances is one of the main challenges in modern chromatography. Special chromatographic columns with specific sorbents are required for their effective separation. The development of new types of chiral sorbents remains crucial, as the increasing quantity of optically active compounds in pharmaceuticals and agricultural chemicals necessitates precise determination of their optical purity. Various types of selectors are used in chiral stationary phases, which can be either low-molecular-weight or high-molecular-weight polymeric materials, synthesized or derived from natural chiral substances. Currently, there is no stationary phase that simultaneously exhibits high enantioselectivity, high chromatographic efficiency, and a broad range of applications. The project plans to use chitosan aminopolysaccharide and its derivatives as chiral selectors. Polycyclic antibiotics will also be used as chiral selectors. The cross-linked chitosan property will be utilized to attach chiral selectors to a porous support, creating an․
Foreign Partner
Marino Lavorgna - PhD,, Research director, Institute of Polymers, Composites and Biomaterials, National Research Council of Italy (IPCB-CNR)
