Laboratory of Biophysics of Subcellular Structures

The Laboratory of Biophysics of Subcellular Structures was founded in 2005.

The field of laboratory research includes:

• study of nucleic acids-ligand interaction (study of biologically active compounds binding to double-stranded DNA, and single-stranded RNA by different mechanisms),

• biologically active, including the interaction of pharmacological compounds with single-stranded DNA, as well as synthetic deoxyhomopolynucleotides,

• interactions of DNA-specific compounds with blood serum protein albumin,

• influence of millimeter-range electromagnetic waves on biological systems at different levels of formation.

The main scientific directions operating in the laboratory

• Studies of the interaction of biologically active compounds with biomacromolecules, DNA, RNA, and proteins using absorption spectroscopy methods,

• The study of nucleic acids, proteins, and their complexes with biologically active compounds using the UM-denaturation method,

• Analysis of the binding of biologically active compounds to biomacromolecules by the Scatchard plot,

• Study of fluorescence properties of complexes of biologically active compounds with biomacromolecules.

Partnerships

The laboratory cooperates with the following institutions:

• RA NAS Laboratory of "Toxicological Research" of the Institute of Physiology named after L.A. Orbeli

• RA NAS "Liquid Phase Free-Radical Reactions" Laboratory of the A. Nalbandian Institute of Chemical Physics,

• Department of Molecular, Cellular and Developmental Biology, University of Michigan (USA),

• Chair of Molecular Physics of YSU Institute of Physics,

• Department of Physical and Colloid Chemistry of YSU Chemistry Faculty,

• Department of Medical Biochemistry and Biotechnology of the Armenian-Russian (Slavic) University.

Staff

1. Poghos Vardevanyan 

2. Ara Antonyan 

3. Marine Parsadanyan 

4. Mariam Shahinyan 

5. Marieta Mikaelyan 

6. Liya Minasbekyan 

7. Gayane Poghosyan 

8. Evelina Sargsyan

Top 5 publications (Scopus, Web of Science 2018-2023)

1. Vardevanyan P.O., Antonyan A.P., Parsadanyan M.A., Shahinyan M.A. Study of the influence of the ionic strength on complex-formation of ethidium bromide with poly(rA)-poly(rU). J. of Biomol. Struct. & Dyn., 2019, v. 37, N5, p. 2493-2498. 
2. Vardevanyan P.O., Parsadanyan M.A., Antonyan A.P., Shahinyan M.A., Karapetyan A.T. Spectroscopic study of interaction of various GCcontent DNA with Hoechst 33258 depending on Na + concentration. J. of Biomol. Struct. and Dyn., 2021, v. 39, N4, p. 1519-152. 
3. Vardevanyan P.O., Antonyan A.P., Parsadanyan M.A., Shahinyan M.A., Petrosyan N.H. //Study of interaction of methylene blue with DNA and albumin. J. of Biomol. Struc. & Dyn.,2022, v. 40, N 17. p. 7779-7785. 
4. Vardevanyan P.O., Parsadanyan M.A., Antonyan A.P., Shahinyan M.A. Study of complexes of Hoechst 33258 with poly(rA)-poly(rU) depending on various ionic strengths in the water-saline solution. J. of Biomol. Struct. and Dyn., 2022, V.40, p. 1182-1188. 
5. Movsesyan Z.O., Antonyan A.P., Vardevanyan P.O. Binding mechanism of methylene blue with single-stranded synthetic polynucleotides poly(rA) and poly(rU). Journal of Applied Spectroscopy, 2023, v.90, N4, p.742-746.