Laboratory of Integrative and Adaptive Physiology of Humans and Animals

The Laboratory of Human and Animal Physiology was established in 1983 and has been part of the Institute of Biology since 2016. In 2025, it was renamed the Laboratory of Human and Animal Integrative and Adaptive Physiology.

The research areas of the laboratory include:

• Physiological research
• Histological research
• Immunohistochemical research
• Hematological research
• Cellular research

The scientific research of the laboratory is focused on assessing the stability of vertebrate ontogenesis and cellular homeostasis in extreme conditions. The main research directions include:

• Evaluation of histopathological changes in the internal organs and different regions of the brain in rats under conditions of multiple sclerosis.
• Evaluation of histopathological changes in the internal organs and different regions of the brain in rats under hypoxia conditions.
• Study of the mechanisms regulating the functions of internal systems under the influence of ecological and technogenic factors.
• Dynamics of cardiovascular system indicators in students and adolescents under various academic workload conditions.

These studies allow for the assessment of the adaptive capacities of biological systems and the development of practical recommendations for health preservation and risk reduction.

Collaborations
The laboratory collaborates with:

• The Institute of Physiology named after L. A. Orbeli, NAS RA
• The "Histogen" Armenian-German Pathology Scientific-Practical Center
• The R. H. Yolyan Blood Center
• The "Davidyan" Laboratories
• The "Astghik" Medical Center

Staff

1. Anna Feliks Karapetyan 
2. Hayk Azat Minasyan 
3. Anna Vladimir Grigoryan 
4. Ruzanna Arsen Shushanyan 
5. Tamara Aram Abgaryan 
6. Lilit Jonik Tosunyan 
7. Milena Grisha Shahbazyan 
8. Zarik Poghos Stepanyan 
9. Tatev Gegham Poghosyan 

Top 5 Publications (Scopus, Web of Science 2019-2024)

1. Ruzanna A. Shushanyan, Hasmik M. Karapetyan, Edita E. Nadiryan, Nikolay V. Avtandilyan, Anna V. Grigoryan, Anna F. Karapetyan / Tissue remodeling during high-altitude pulmonary edema in rats: Biochemical and histomorphological analysis / Tissue and Cell / 2025, 93, 102727
2. Ruzanna A. Shushanyan, Nikolay V. Avtandilyan, Anna V. Grigoryan, Anna F. Karapetyan / The role of oxidative stress and neuroinflammatory mediators in the pathogenesis of high-altitude cerebral edema in rats / Respiratory Physiology and Neurobiology , 2024, 327(9), 104286
3. Emma Gevorkyan, Ruzanna Shushanyan, Karine Hovhannisyan, Marietta Karapetyan, Anna Karapetyan / ASSESSMENT OF CHANGES IN HEART RATE VARIABILITY INDICES OF STUDENTS AFTER COVID-19 LOCKDOWN: A COHORT STUDY / Медицинские новости Грузии (Georgian medical news) / 2024, No 9 (354), 199-204 
4. Zhenya Yavroyan, Anna Grigoryan, Nune Hakobyan, Agapi Hovhannisyan, Tamara Abgaryan, Anna Karapetyan, Emil Gevorgyan / Cisplatin and dexamethasone separate and combined effect on nephrotoxic processes in female rats. / Ukrainian Journal of Nephrology and Dialysis / 2024, 84(4), 64-74
5. R.A. Shushanyan / THE EVALUATION OF MAST CELLS, TNF-α EXPRESSION AND TUNEL- POSITIVE NEURONS IN THE BRAIN DURING INFLAMMATORY RESPONSE INDUCED BY ACUTE HYPOBARIC HYPOXIA / Proceedings of the YSU B: Chemical and Biological Sciences 2024/ 86-94