Signal transduction and experimental pathology research group from
The primary research focus of the Signal transduction and experimental pathology group is the quantitative and qualitative analysis of key components within signaling pathways activated during various pathological conditions. These include oxygen deprivation (hypoxia), inflammation, pathological angiogenesis, impaired wound healing, and oxidative stress. Our investigations are centered on understanding the progression of these pathological mechanisms in the context of cancer, diabetes, and hypoxia.
Experimental studies will be conducted using in vivo animal models to assess treatment-induced alterations in multiple target organs, with a particular emphasis on bone marrow involvement. Complementary in vitro studies are also performed on commercial breast cancer cell lines to explore molecular responses under cancerous and hypoxic conditions. The group work also focuses on elucidating the molecular mechanisms of resistance formation to antineoplastic drugs, with an emphasis on components of the HIF-1 (hypoxia-inducible factor-1) cell signaling pathway.
Our research aims to uncover critical signaling dynamics driving disease progression and to identify potential therapeutic targets for more effective treatment strategies.
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